Introduction: Chemically they are reducing agents. They oxidize themselves and prevent oxidation of API. A substance that inhibits oxidation is called antioxidants. The effectiveness of antioxidant can depend on the concentration used and pH of solution. Examples: Ascorbic acid, butylated hydroxy anisole (BHA), butylated hydroxyl toluene (BHT) Oxidation is a chemical reaction involving the loss of electrons or an increase in oxidation state. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When the chain reaction occurs in a cell, it can cause damage or death to the cell. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. The following are some of the qualities of an ideal anti-oxidant: It should be readily soluble or dispersible in the medium. It should be effective in low concentration. It should be non-toxic. It should be non-irrita
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