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APPARENT VOLUME OF DISTRIBUTION

APPARENT VOLUME OF DISTRIBUTION:- Ø   Apparent volume of distribution and clearance are two separate and independent pharmacokinetic characteristics of a drug. Since they are closely related with physiologic mechanisms in the body, they are called as primary parameters.         V d =     Amount of drug in the body    =     X ------ 12                        Plasma drug concentration          C Ø   V d is a measure of the extent of distribution of drug and is expressed in litres. The best and simplest way of estimating V d of a drug is administering it by rapid IV injection and using following equation:         V d =    Xo / Co = iv bolus dose / Co  ------13 Ø   Equation 13 can only b...

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