APPARENT VOLUME OF DISTRIBUTION
APPARENT VOLUME OF DISTRIBUTION:- Ø Apparent volume of distribution and clearance are two separate and independent pharmacokinetic characteristics of a drug. Since they are closely related with physiologic mechanisms in the body, they are called as primary parameters. V d = Amount of drug in the body = X ------ 12 Plasma drug concentration C Ø V d is a measure of the extent of distribution of drug and is expressed in litres. The best and simplest way of estimating V d of a drug is administering it by rapid IV injection and using following equation: V d = Xo / Co = iv bolus dose / Co ------13 Ø Equation 13 can only b...