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SOP for Semi Automatic capsule filling machine

GENERAL REQUIREMENT: 1.1 The environment condition in which filling of hard gelatin capsule should be normally carried out is:                         Humidity:                 Not more than 35% RH                         Temperature:         Not more than 25%             These conditions should be maintain even work has stopped at the end of   working day and during                                    the week- ends. 1.2 The area around machine should be kept clean at all times. ...
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Various Capsule Filling Machine

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ADU-100 AIR DISPLACEMENT UNIT Ø   The ADU-100 is a dust extraction unit. Ø   It is used for collecting loose powder from them polishing chamber of the DP-100. Ø   It is also used for cleaning operations on automatic capsule filling machines. Ø   The unit removes loose powder, caps, bodies, and capsules lying around the machine. Ø   It can also be coupled with tableting machines for dust collection. METAL DETECTION SYSTEM:      The Metal Detection system works on the Eddy Current Principle using a Focused electromagnetic field.     It uses Dual Channel Phase Sensitive Detection for optimum detection of all metals (ferrous and non-ferrous / non-magnetic stainless steel).        It detects very minute particles of stainless steel and metal flakes inadvertently present in formulations. DP- 100 DE – DUSTING AND POLISHING MACHINE: Ø   The DP-100 is ...
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AF – 90 (T) – AUTOMATIC CAPSULE FILLING MACHINE

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      Ø   The AF-90T is a fully automatic capsule-filling machine that can fill a large variety of powder formulations into hard gelatin capsules. Ø   The machine is formulation friendly and uses a tamping principle to form a slug, which is inserted, into his empty capsule. Ø   A pellet filling / tablet filling / capsule in capsule device are available as an optional attachment. Output • Up to 90,000 capsules / hour for powder filling                Up to 80,000 capsules /hour for pellet filling                Up to 75,000 capsules /hour for tablet filling Ø   Conforming to cGMP. Ø   High filling accuracy due to precise slug dosing principle• Partial filling capability for any size of capsule with extra dosing disc. Ø   Better yield due to high filling accuracy and no po...
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FCE – 100 FILLED CAPSULE ELEVATOR

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The FCE-100 is a high output elevator suitable for elevating from a lower level to higher level. This unit is extremely useful in fully automatic lines where the output from the exit chute of a filling/sorting machine, which is at a lower level, is connected to the inlet chute of a polishing machine, which is at a higher level. Salient Features • Can convey all capsule sizes from 00 to 5 • Inbuilt blower unit • GMP conforming design • All contact parts are of stainless steel approved inert materials
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AUTOMATIC CAPSULE FILLING:

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AUTOMATIC CAPSULE FILLING TRANSFER LINE READY TO BLISTER PACK 1. EMPTY CAPSULE SORTER ELEVATOR SE-100 2. AUTOMATIC CAPSULE FILLING M/C [AF-90(T)] 3. AIR DISPLACEMENT UNIT – ADU 4. AUTOMATIC PROCDUCT CONVEYING SYSTEM –PCS – 100 5. ON LINE METAL DETECTION SYSTEM 6. ON LINE CHECK WEIGHER CW- 10 7. DEDUSTING & POLISHING MACHINSE DP – 100 8. MINI CAPSULE SORTER MCS – 100 9. EMPTY CAPSULE ELIMINATOR ECS -100
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Introduction of Latin to English, weights and measures in dispensing pharmacy

Definition: It is defined as supply of medicine to individual patients according to the prescription written by registered medical practitioner. General dispensing procedure: o    Give the prescription. o    Check out dose and direction of dispensing. o    Dispense the medicine. o    Take a medicine into a container. o    Fix the label onto the container. o    Supply the container to the patient with conditions associated with medicine. Introduction of latin to english translation Latin Terms and Abbreviations Term or Phrase Abbreviation Meaning Quantum q.s.   As much Sufficiat as is sufficient sufficit  as is sufficient Sufficientem q.s. As ...
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PATIENT RELATED FACTORS AFFECTING ON DRUG ABSORPTION

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Physiologic Factors Related to Drug Absorption:   The systemic absorption of a drug is dependent on   The physicochemical properties of the drug,   The nature of the drug product, and   The anatomy and physiology of the drug absorption site.  1. Membrane Physiology A. Nature of Cell Membrane  The fluid mosaic model, proposed by , explains the transcellular diffusion of polar molecules.   According to this model, the cell membrane consists of globular proteins embedded in a dynamic fluid, lipid bilayer matrix. These proteins provide a pathway for the selective transfer of certain polar molecules and charged ions through the lipid barrier.  As shown in , transmembrane proteins are interdispersed throughout the membrane. Two types of pores of about 10 nm and 50 to 70 nma were inferred to be present in membranes based on capillary membrane transport studies. These small pores provide a channel through which water, ions, and dissol...
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PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

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PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                       ...
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