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NON-COMPARTMENTAL MODEL

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Also called as the model independent method, as does not require assumption of specific compartment model. Ø   Non – compartmental models describe the pharmacokinetics of drug disposition using time and concentration parameters. Ø   This method can however be applied to any compartment model provided the drugs or metabolites follow linear kinetics. Ø   The approach based on statistical moments theory, involves the collection of experimental data following a single dose of drug. Ø   If one considers the time course of drug concentration in plasma as a statistical distribution curve, then: MRT = AUMC                            AUC Where MRT= Mean residence time             AUMC= area under the first moment curve           ...

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