Posts

Showing posts with the label ANOVA

BIOEQUIVALENCE: Its type and method of studying bioequivalence

Image
BIOEQUIVALENCE: It‘s commonly observed that there are several formulations of the same drug, in the same dose, in similar dosage form and meant to be given by the same route. in order to ensure clinical performance of such drug products, bioequivalence studies should be performed. TYPES  OF  EQUIVALENCE Chemical Equivalence:  When 2 or more drug products contain the same labeled chemical substance as an active ingredient in the same amount.  Pharmaceutical Equivalence:  When two or more drug products are identical in strength, quality, purity, content uniformity, disintegration and dissolution characteristics; they may however differ in excipients.  Bioequivalence:  A relative term which denotes that the drug substance in two or more dosage forms, reaches the systemic circulation at the same relative rate and to the same relative extent i.e., their plasma concentration time profiles will be identical without significant statistic...
Post a Comment
Keep reading

Popular posts from this blog

Introduction of Latin to English, weights and measures in dispensing pharmacy

Definition: It is defined as supply of medicine to individual patients according to the prescription written by registered medical practitioner. General dispensing procedure: o    Give the prescription. o    Check out dose and direction of dispensing. o    Dispense the medicine. o    Take a medicine into a container. o    Fix the label onto the container. o    Supply the container to the patient with conditions associated with medicine. Introduction of latin to english translation Latin Terms and Abbreviations Term or Phrase Abbreviation Meaning Quantum q.s.   As much Sufficiat as is sufficient sufficit  as is sufficient Sufficientem q.s. As ...
Keep reading

PATIENT RELATED FACTORS AFFECTING ON DRUG ABSORPTION

Image
Physiologic Factors Related to Drug Absorption:   The systemic absorption of a drug is dependent on   The physicochemical properties of the drug,   The nature of the drug product, and   The anatomy and physiology of the drug absorption site.  1. Membrane Physiology A. Nature of Cell Membrane  The fluid mosaic model, proposed by , explains the transcellular diffusion of polar molecules.   According to this model, the cell membrane consists of globular proteins embedded in a dynamic fluid, lipid bilayer matrix. These proteins provide a pathway for the selective transfer of certain polar molecules and charged ions through the lipid barrier.  As shown in , transmembrane proteins are interdispersed throughout the membrane. Two types of pores of about 10 nm and 50 to 70 nma were inferred to be present in membranes based on capillary membrane transport studies. These small pores provide a channel through which water, ions, and dissol...
Keep reading

PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

Image
PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                       ...
Keep reading

Facebook Page

Knowledge of Pharma