Knowledge of Pharma

Dissolution Profile: Dissolution profile is the complete dissolution behavior of a dosage form including dissolution rate and extent of dissolution. OR It is graphical representation (Concentration Vs Time) of complete release of A.P.I from a dosage form in  an appropriate selected dissolution medium . Important of dissolution profile comparison: To study the variations of dissolution profile within a batch or from batch to batch of the same brand to assure uniformity of dissolution and thus bioavailability, specifically in law margin drugs. For optimizing the dosage formula by comparing the dissolution profile of the same A.P.I. Dissolution profile of an A.P.I. reflects its release pattern under the selected condition sets. Methods for comparison: —   Model Dependent Method —   Model Independent Method Model Dependent Method: —   Zero order A.P.I. release             ...

Apparatus: - 7 (Reciprocating holder) Specified for use with a variety of dosage forms. Apparatus:- C onsists of a set of volumetrically calibrated or tarred solution containers made of glass or suitable material, a motor and driven assembly to reciprocate the system vertically or horizontally, and a set of suitable sample holder. Dissolution medium:- As specified in the individual monograph. S ample preparation A (Coated tablet drug delivery system):-   Attach each system to be tested to a suitable sample holder. (By gluing, placing into small nylon bag or metal coil.) Sample preparation B (Trans dermal drug delivery system):-   Attach the system to a suitable sized sample holder with a suitable O- ring. Sample preparation C (Other drug delivery system):- Attach each system to be tested to a suitable sample holder as described in individual monograph.  Procedure:- S uspend sample holder from a vertically reciprocating shaker that...