COMPARISON OF DISSOLUTION PROFILE
Dissolution Profile: Dissolution profile is the complete dissolution behavior of a dosage form including dissolution rate and extent of dissolution. OR It is graphical representation (Concentration Vs Time) of complete release of A.P.I from a dosage form in an appropriate selected dissolution medium . Important of dissolution profile comparison: To study the variations of dissolution profile within a batch or from batch to batch of the same brand to assure uniformity of dissolution and thus bioavailability, specifically in law margin drugs. For optimizing the dosage formula by comparing the dissolution profile of the same A.P.I. Dissolution profile of an A.P.I. reflects its release pattern under the selected condition sets. Methods for comparison: Model Dependent Method Model Independent Method Model Dependent Method: Zero order A.P.I. release ...