Pharmaceutical factors affecting drug absorption
Definitions Pharmacokinetics o Evaluate the way in which a drug interacts with various barriers within a biological system Pharmacodynamics o Study of the relationship between systemic exposure of a drug and it’s biological effects on tissue o Absorption can be defined as the movement of active drug (or prodrug) from the site of administration across biologic barriers into a site where it is measured in the blood. This site of measurement is not specified. o Bioavailability can be defined as the fraction of administered drug that reaches the systemic circulation. o Note the difference in endpoint measurement sites PHARMACEUTICAL FACTORS: It include factors relating to the- A. Chemical Factors o A variety of chemical options can be used to improve the stability and systemic availability of drugs. o For example, esters can be p...