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Dissolution apparatus: apparatus 5 (paddle overdisk) & apparatus 6

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Apparatus:-5 (Peddle Over Disk): Apparatus : -   Use apparatus – 2, with addition of a stainless steel assembly designed for holding transdermal system at the bottom of the vessel. Temperature: 37 ± 0.05°. Distance between Peddle & Disk: 25 ± 2 mm. Dead volume is kept in mind. Disk assembly holds the system flat & is positional such that the release surface is parallel with bottom of the paddle blade. Apparatus suitability test & Dissolution medium :-  Proceed as directed for apparatus : 2. Procedure:- Place dissolution medium & apply the transdermal system to the disk assembly in such a way so that releasing surface facing up. Time: - The test time points, generally three, are expressed in hrs. S ample withdrawn within a tolerance of ± 15 mins. & ±2 %. Interpretation : -  Quantities of the active ingredient released from the system confirm to Acceptance table. Level No. Tested Criteria L1 ...
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