Pulsincap drug delivery system

 Pulsincap is a novel approach to modified capsule drug delivery that provides controlled and targeted release of drugs. This approach involves the use of specialized capsules that are designed to release their contents in a pulsatile manner, which mimics the natural pattern of drug release in the body.

The Pulsincap approach utilizes a two-component system consisting of a hard gelatin capsule and a pulsatile release insert. The hard gelatin capsule serves as a shell for the insert, which contains the drug and is designed to release it in a controlled and targeted manner.

Working Principle:

The Pulsincap approach is based on the principle of pulsatile drug delivery. Pulsatile drug delivery refers to the delivery of drugs in a series of pulses or bursts, which mimic the natural physiological pattern of drug release in the body.

The pulsatile release insert is designed to release the drug in a pulsatile manner by using a combination of swelling and erosion mechanisms. The insert consists of two or more compartments, each containing a different drug formulation or dose. The compartments are separated by a swelling or eroding barrier that controls the release of the drug.

When the Pulsincap capsule is ingested, it first passes through the stomach and into the small intestine. The pH of the small intestine triggers the swelling or erosion of the barrier between the compartments in the insert. This allows the drug to be released in a controlled and targeted manner, mimicking the natural pattern of drug release in the body.

Advantages:

The Pulsincap approach offers several advantages over traditional drug delivery systems. These include:

  1. Targeted drug delivery: The Pulsincap approach allows for targeted drug delivery to specific sites in the body, which can reduce side effects and increase efficacy.

  2. Controlled drug release: The Pulsincap approach provides controlled and predictable drug release, which can improve patient compliance and reduce the need for frequent dosing.

  3. Flexibility: The Pulsincap approach allows for the combination of multiple drugs or doses in a single capsule, which can improve treatment outcomes and reduce the number of capsules required.

  4. Improved bioavailability: The Pulsincap approach can improve the bioavailability of drugs by delivering them to the small intestine, where absorption is more efficient.

  5. Reduced side effects: The Pulsincap approach can reduce side effects by releasing the drug in a pulsatile manner, which mimics the natural pattern of drug release in the body.

Limitations:

The Pulsincap approach also has some limitations. These include:

  1. Complex design: The Pulsincap approach requires a complex design that may increase the cost of production.

  2. Limited drug compatibility: The Pulsincap approach may be limited in terms of drug compatibility due to the need for a specific drug formulation.

  3. Limited market availability: The Pulsincap approach is a relatively new technology and may not be widely available in the market.

  4. Limited application: The Pulsincap approach may have limited application in certain disease states or conditions.

Examples:

Some examples of drugs that have been formulated using the Pulsincap approach include:

  1. Metoprolol succinate: This drug is used to treat hypertension and is formulated as a Pulsincap to provide controlled and targeted release.

  2. Verapamil hydrochloride: This drug is used to treat angina and is formulated as a Pulsincap to provide pulsatile release.

  3. Theophylline: This drug is used to treat asthma and is formulated as a Pulsincap to provide targeted and controlled release.

In conclusion, the Pulsincap approach is a novel technology for modified capsule drug delivery that provides controlled and targeted release of drugs. It offers several advantages over traditional drug delivery systems, including targeted drug delivery

Comments

Post a Comment

Popular posts from this blog

PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

Image
PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                                     Colorants                                     Opecifier (TiO2 Dyes and Other)                                     Preservative MANUFACTURING OF HGC SHELL: SFR-901 FULLY AUTOMATIC CAPSULE MACHINE: FEATURES OF SFR-901 Ø   The Safrroys SFR-901 mod
Keep reading

2. Extensive literature survey:

Image
Once the problem is formulated, a brief summary of it should be written down. It is compulsory for a research worker writing a thesis for a Ph.D. degree to write a synopsis of the topic and submit it to the necessary Committee or the Research Board for approval.   At this juncture the researcher should undertake extensive literature survey connected with the problem. For this purpose, the abstracting and indexing journals and published or unpublished bibliographies are the first place to go to. Academic journals, conference proceedings, government reports, books etc., must be tapped depending on the nature of the problem. In this process, it should be remembered that one source will lead to another. The earlier studies, if any, which are similar to the study in hand, should be carefully studied. A good library will be a great help to the researcher at this stage.
Keep reading

PREPARATION OF HOSPITAL FORMULARY

Image
PREPARATION OF FORMULARY ·          Formulation is an essential part of hospital pharmacy. ·          It has been a focal point for improving drug therapy in hospitals. ·          Effectiveness of formulary system depends on the abilities of the pharmacist involved with it. ·          Although the majority of formulary decisions are made by Pharmacy and Therapeutic Committee but well planned system provides both structure and flexibility and encompasses both selection of drugs and criteria for drug use. ·          These special features allow for standardization to reduce errors, wastage and required personnel time. Advantage: ·          To discourage the use of “less than optimal drug therapy”, and ·          To provide generic product list. o    Generic product selection policies stimulate bio-equivalency comparison which prevents the unnecessary stocking of less than optimal products. ·          Formularies must include cost to provide relative cost data
Keep reading

Facebook Page

Knowledge of Pharma