Formulation: In situ gels as occular products

 In situ gels are a class of formulations that transform from a liquid to a gel-like consistency once they come into contact with a particular trigger. These formulations are commonly used in the pharmaceutical industry for drug delivery applications due to their ability to provide sustained drug release and improved patient compliance. In the field of ocular drug delivery, in situ gels have gained popularity as an alternative to conventional eye drops. In this article, we will discuss in situ gels as ocular products and describe two commercial products, Occusert and Lacrisert.

What are In Situ Gels?

In situ gels are liquid formulations that transform into a gel-like consistency once they come into contact with a specific trigger, such as body temperature or pH. This transformation can occur either spontaneously or in response to an external stimulus, such as light or heat. In the case of ocular drug delivery, in situ gels are designed to undergo gelation once they come into contact with the tear fluid of the eye, providing sustained drug release and improved bioavailability.

Advantages of In Situ Gels for Ocular Drug Delivery In situ gels have several advantages over conventional eye drops for ocular drug delivery. Firstly, they can provide sustained drug release, reducing the need for frequent dosing and improving patient compliance. Secondly, they can improve the bioavailability of drugs by prolonging their contact time with the eye. Finally, in situ gels can improve the retention of drugs in the eye, reducing the amount of drug that is wasted and improving the overall efficacy of the treatment.

Occusert Occusert is a commercial in situ gel product for the treatment of glaucoma. It is a biodegradable, sustained-release formulation that contains the drug pilocarpine. The formulation is designed to undergo gelation once it comes into contact with the tear fluid of the eye, providing sustained drug release over a period of 7-14 days. The product is administered via a small, punctal plug that is inserted into the lower punctum of the eye. The plug slowly dissolves over time, releasing the drug into the eye.

Lacrisert Lacrisert is another commercial in situ gel product for the treatment of dry eye syndrome. It is a biodegradable, sustained-release formulation that contains the drug hydroxypropyl cellulose. The formulation is designed to undergo gelation once it comes into contact with the tear fluid of the eye, providing sustained lubrication and hydration for up to 12 hours. The product is administered via a small, rod-shaped insert that is placed into the lower conjunctival sac of the eye. The insert slowly dissolves over time, releasing the drug and providing sustained relief from dry eye symptoms.

In conclusion, in situ gels are a promising area of research for ocular drug delivery. They have several advantages over conventional eye drops, including sustained drug release, improved bioavailability, and improved patient compliance. Occusert and Lacrisert are two examples of commercial in situ gel products for the treatment of glaucoma and dry eye syndrome, respectively. These products demonstrate the potential of in situ gels as ocular drug delivery systems and the significant benefits they can provide to patients.

Comments

Post a Comment

Popular posts from this blog

PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

Image
PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                       ...
Keep reading

2. Extensive literature survey:

Image
Once the problem is formulated, a brief summary of it should be written down. It is compulsory for a research worker writing a thesis for a Ph.D. degree to write a synopsis of the topic and submit it to the necessary Committee or the Research Board for approval.   At this juncture the researcher should undertake extensive literature survey connected with the problem. For this purpose, the abstracting and indexing journals and published or unpublished bibliographies are the first place to go to. Academic journals, conference proceedings, government reports, books etc., must be tapped depending on the nature of the problem. In this process, it should be remembered that one source will lead to another. The earlier studies, if any, which are similar to the study in hand, should be carefully studied. A good library will be a great help to the researcher at this stage.
Keep reading

PREPARATION OF HOSPITAL FORMULARY

Image
PREPARATION OF FORMULARY ·          Formulation is an essential part of hospital pharmacy. ·          It has been a focal point for improving drug therapy in hospitals. ·          Effectiveness of formulary system depends on the abilities of the pharmacist involved with it. ·          Although the majority of formulary decisions are made by Pharmacy and Therapeutic Committee but well planned system provides both structure and flexibility and encompasses both selection of drugs and criteria for drug use. ·          These special features allow for standardization to reduce errors, wastage and required personnel time. Advantage: ·          To discourage the use of “less than optimal drug therapy”, and ·     ...
Keep reading

Facebook Page

Knowledge of Pharma