Principal for dosage form design

 There are several principles of dosage form design in pharmaceutics that are used to create safe, effective, and stable drug formulations. Some of the essential principles are:

  1. Biopharmaceutics: The principles of biopharmaceutics involve understanding the physicochemical properties of the drug and how they affect the drug's absorption, distribution, metabolism, and elimination (ADME) in the body. This information is used to design dosage forms that optimize drug delivery and bioavailability.

  2. Pharmacokinetics: The principles of pharmacokinetics involve understanding how drugs are absorbed, distributed, metabolized, and eliminated in the body. This information is used to design dosage forms that optimize drug delivery and efficacy.

  3. Drug stability: The principles of drug stability involve understanding how drugs degrade over time due to various factors such as temperature, humidity, light, and pH. This information is used to design dosage forms that ensure drug stability and shelf-life.

  4. Formulation development: The principles of formulation development involve selecting appropriate excipients and processing methods to create dosage forms that are safe, effective, and stable. The formulation development process also considers factors such as patient compliance, ease of administration, and cost-effectiveness.

  5. Quality control: The principles of quality control involve ensuring that dosage forms meet regulatory standards for safety, efficacy, and quality. This involves testing for factors such as drug potency, uniformity of dosage, and impurities.

Overall, the principles of dosage form designing in pharmaceutics involve a thorough understanding of the drug's properties and how they interact with various excipients and processing methods. Pharmaceutical companies can create safe and effective drugs that improve patient outcomes by optimizing drug delivery, stability, and quality.

Comments

Post a Comment

Popular posts from this blog

PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

Image
PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                       ...
Keep reading

2. Extensive literature survey:

Image
Once the problem is formulated, a brief summary of it should be written down. It is compulsory for a research worker writing a thesis for a Ph.D. degree to write a synopsis of the topic and submit it to the necessary Committee or the Research Board for approval.   At this juncture the researcher should undertake extensive literature survey connected with the problem. For this purpose, the abstracting and indexing journals and published or unpublished bibliographies are the first place to go to. Academic journals, conference proceedings, government reports, books etc., must be tapped depending on the nature of the problem. In this process, it should be remembered that one source will lead to another. The earlier studies, if any, which are similar to the study in hand, should be carefully studied. A good library will be a great help to the researcher at this stage.
Keep reading

PREPARATION OF HOSPITAL FORMULARY

Image
PREPARATION OF FORMULARY ·          Formulation is an essential part of hospital pharmacy. ·          It has been a focal point for improving drug therapy in hospitals. ·          Effectiveness of formulary system depends on the abilities of the pharmacist involved with it. ·          Although the majority of formulary decisions are made by Pharmacy and Therapeutic Committee but well planned system provides both structure and flexibility and encompasses both selection of drugs and criteria for drug use. ·          These special features allow for standardization to reduce errors, wastage and required personnel time. Advantage: ·          To discourage the use of “less than optimal drug therapy”, and ·     ...
Keep reading

Facebook Page

Knowledge of Pharma