ONE COMPARTMENT OPEN MODEL(Instantaneous Distribution Model)


·         The one compartment open model is the simplest model which depicts the body as a single, kinetically homogeneous unit having no barriers to the movement of drug and final distribution equilibrium between drug in plasma and other body fluid is obtained instantaneously and maintained at all times.
·         This model thus applies only to those drugs that distribute rapidly throughout the body.
·         The anatomical reference compartment is the plasma and concentration of drug in plasma is representative of drug concentration in all body tissues i.e. any change in plasma drug concentration reflects a proportional change in drug concentration throughout the body.
·         The term open indicates that the input (availability) and output (elimination) are unidirectional and that the drug can be eliminated from the body.



One compartment open model is generally used to describe plasma levels following administration of a single dose of a drug. Depending upon the rate of input, several one compartment open models can be defined:

1.      One compartment open model, intravenous bolus administration
2.      One compartment open model, continuous intravenous infusion
3.      One compartment open model, extravascular administration, zero order absorption and
One compartment open model, extravascular administration, first order absorption.

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