Effect of Organoleptic Properties on preformulation

1.      Organoleptic Properties:



·         Properties which are evaluated after an impression on the organs of sense.
·         Like, colour, odour, flavour, taste, size, shape, touch, texture etc.
·         A typical preformulation program should beginwith the description of the drug substance.

Table 1: Terminology to describe organolepticproperties of pharmaceutical powders.
Colour
Odour
Taste
Off-white
Pungent
Acidic
Creamyellow
Sulfurous
Bitter
Tan
Fruity
Bland
Shiny
Aromatic
Intense

Odouerless
Sweet


Tasteless
·         Color:
o   Color is generally a function of drug’s chemical structure
o   Color intensity relates to extend of conjugated unsaturation as well as the presence of chromophores.
·         Odour:
o   Inherent odour due to major functional groups present
o   Odour greatly affects the flavor of a preparation.
·         Taste:
o   Unpalatable taste à less soluble chemical form of the drug
The odour and taste may be suppressed by using appropriate flavors and excipients or by coating the final product.

Comments

Post a Comment

Popular posts from this blog

PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

Image
PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                                     Colorants                                     Opecifier (TiO2 Dyes and Other)                                     Preservative MANUFACTURING OF HGC SHELL: SFR-901 FULLY AUTOMATIC CAPSULE MACHINE: FEATURES OF SFR-901 Ø   The Safrroys SFR-901 mod
Keep reading

2. Extensive literature survey:

Image
Once the problem is formulated, a brief summary of it should be written down. It is compulsory for a research worker writing a thesis for a Ph.D. degree to write a synopsis of the topic and submit it to the necessary Committee or the Research Board for approval.   At this juncture the researcher should undertake extensive literature survey connected with the problem. For this purpose, the abstracting and indexing journals and published or unpublished bibliographies are the first place to go to. Academic journals, conference proceedings, government reports, books etc., must be tapped depending on the nature of the problem. In this process, it should be remembered that one source will lead to another. The earlier studies, if any, which are similar to the study in hand, should be carefully studied. A good library will be a great help to the researcher at this stage.
Keep reading

PREPARATION OF HOSPITAL FORMULARY

Image
PREPARATION OF FORMULARY ·          Formulation is an essential part of hospital pharmacy. ·          It has been a focal point for improving drug therapy in hospitals. ·          Effectiveness of formulary system depends on the abilities of the pharmacist involved with it. ·          Although the majority of formulary decisions are made by Pharmacy and Therapeutic Committee but well planned system provides both structure and flexibility and encompasses both selection of drugs and criteria for drug use. ·          These special features allow for standardization to reduce errors, wastage and required personnel time. Advantage: ·          To discourage the use of “less than optimal drug therapy”, and ·          To provide generic product list. o    Generic product selection policies stimulate bio-equivalency comparison which prevents the unnecessary stocking of less than optimal products. ·          Formularies must include cost to provide relative cost data
Keep reading

Facebook Page

Knowledge of Pharma