Effect of Organoleptic Properties on preformulation

1.      Organoleptic Properties:



·         Properties which are evaluated after an impression on the organs of sense.
·         Like, colour, odour, flavour, taste, size, shape, touch, texture etc.
·         A typical preformulation program should beginwith the description of the drug substance.

Table 1: Terminology to describe organolepticproperties of pharmaceutical powders.
Colour
Odour
Taste
Off-white
Pungent
Acidic
Creamyellow
Sulfurous
Bitter
Tan
Fruity
Bland
Shiny
Aromatic
Intense

Odouerless
Sweet


Tasteless
·         Color:
o   Color is generally a function of drug’s chemical structure
o   Color intensity relates to extend of conjugated unsaturation as well as the presence of chromophores.
·         Odour:
o   Inherent odour due to major functional groups present
o   Odour greatly affects the flavor of a preparation.
·         Taste:
o   Unpalatable taste à less soluble chemical form of the drug
The odour and taste may be suppressed by using appropriate flavors and excipients or by coating the final product.

Comments

Post a Comment

Popular posts from this blog

PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

Image
PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                                     Colorants                                     Opecifier (TiO2 Dyes and Other)                                     Preservative MANUFACTURING OF HGC SHELL: SFR-901 FULLY AUTOMATIC CAPSULE MACHINE: FEATURES OF SFR-901 Ø   The Safrroys SFR-901 mod
Keep reading

ANTIOXIDANTS: In Pharmaceutical Formulation

Image
Introduction: Chemically they are reducing agents. They oxidize themselves and prevent oxidation of API. A substance that inhibits oxidation is called antioxidants. The effectiveness of antioxidant can depend on the concentration used and pH of solution. Examples:  Ascorbic acid,  butylated hydroxy anisole (BHA),  butylated hydroxyl toluene (BHT) Oxidation is a chemical reaction involving the loss of electrons or an increase in oxidation state. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When the chain reaction occurs in a cell, it can cause damage or death to the cell. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. The following are some of the qualities of an ideal anti-oxidant: It should be readily soluble or dispersible in the medium. It should be effective in low concentration. It should be non-toxic. It should be non-irrita
Keep reading

3. Development of working hypothesis:

Image
After extensive literature survey, researcher should state in clear terms the working hypothesis or hypotheses. Working hypothesis is tentative assumption made in order to draw out and test its logical or empirical consequences. As such the manner in which research hypotheses are developed is particularly important since they provide the focal point for research. They also affect the manner in which tests must be conducted in the analysis of data and indirectly the quality of data which is required for the analysis. In most types of research, the development of working hypothesis plays an important role. Hypothesis should be very specific and limited to the piece of research in hand because it has to be tested. The role of the hypothesis is to guide the researcher by delimiting the area of research and to keep him on the right track. It sharpens his thinking and focuses attention on the more important facets of the problem. It also indicates the type of data required
Keep reading

Facebook Page

Knowledge of Pharma