LIST OF FACTORS AFFECTING DRUG ABSORPTION




PHARMACEUTICAL FACTORS
A.    Chemical factors
B.     Physicochemical properties of drug substances
1.      Drug solubility & dissolution rate
2.      Particles size & effective surface area
3.      Polymorphism & amorphism
4.      Solvates & hydrates
5.      Salt form of drug
6.      Ionization state
7.      Drug pKa & lipophilicity & GI pH ---pH partition hypothesis.
C.    Formulation Factors
1.      Disintegration time
2.      Manufacturing variables
                                                                    i.      Method of granulation
                                                                  ii.      Compression force
3.      Nature & type of dosage form
4.      Pharmaceutical ingredients
5.      Product age & storage conditions

PATIENT RELATED FACTORS 
      A.    PHYSIOLOGICAL FACTORS
1.      Membrane physiology
                                                                    i.      Nature of cell membrane
2.      Transport processes
3.      Gastero-Intestinal motility
4.      Gastric emptying rate
5.      Intestinal motility
6.      Drug stability in GIT
7.      pH of GIT
8.      Surface area of GIT
9.      Intestinal transit
10.  Blood flow to GIT.
11.  Effect of food
12.  Age

      B.     CLINICAL FACTORS 
     
     Please click on topic for further reading...
     Description of every factore given in separate post.
     Thanks..

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