Hard Gelatin Capsule (HGC)


HARD GELATIN CAPSULE

The hard gelatin capsule consists of a base or body and a shorter cap, which fits firmly over the base of the capsule.


ADVANTAGES:

1. They may be used to mask the unpleasant tastes, aromas, or appearance of a drug.

2. They allow powders to be dispensed in an uncompressed form, thus allowing for quicker dissolution and                        absorption of the drug following oral dosing (as compared with tablets).

3. They offer the pharmacist versatility to prepare any dose desired for a variety of administration routes             (e.g. oral, inhalation, rectal, or to be diluted for vaginal, rectal, oral or topical use).

4. They may be easier than tablets for some people to swallow.

5. They can be making to alter the release rate of the drug.

6. They are available in various sizes.

7. They can be colored to protect the content (photosensitive) from light and improve the acceptability.

8. Required less excipient than tablets


DISADVANTAGES:

1. They are easily tampered with (although techniques exist for preventing this).

2. They are subject to the effects of relative humidity and to microbial contamination.

3. More expensive (commercially).

4. Bulk dosage cannot be dispensed in capsule.


PHYSICAL SPECIFICATION FOR HSG:
Size
Outer Diameter (mm)
Height or Locked Length (mm)
Actual Volume (ml)
Typical Fill Weights (mg) 0.70 Powder Density
000
9.91
26.14
1.37
960
00
8.53
23.30
0.95
665
0
7.65
21.70
0.68
475
1
6.91
19.40
0.50
350
2
6.35
18.00
0.37
260
3
5.82
15.90
0.30
210
4
5.31
14.30
0.21
145
5
4.91
11.10
0.13
90


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