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General Material used for Nano Formulations

1 Materials    P olymer Methods of  NPs preparation Polymers Monomers polymerization Poly(alkyl cyanoacrylate) Poly(alkyl methacrylate) Poly(styrene) Poly(vinylpyridine) Nanoprecipitation Poly( ε- caprolactone) Poly(lactic acid) Poly(lactic-co-glycolic acid) Poly(methacrylate) Solvent evaporation Poly(ε-caprolactone) Poly(lactic acid) Poly(lactic-co-glycolic acid) Poly(β-hydroxybutyrate) Ethyl cellulose Salting out Cellulose acetate phthalate Poly(alkyl methacrylate) Ethyl cellulose Poly(lactic acid) Poly(lactic-co-glycolic acid) Desolvation,   denaturation,   ionic gelation Albumin Casein Gelatin Alginate Chitosan Ethyl cellulose Stabilizers Generally surfactants are used as stabi...
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Nano-Technology: An Overview

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HISTORY Prof. Paul Ehrlich gave the concept of “magic bullet” for drug targeting. Prof. Peter Paul Speiser and his co-workers developed first nanoparticles for drug delivery purpose and for vaccines in the late 1960s. NANOTECHNOLOGY Nanotechnology is the design, characterization, production and application of structures, devices and systems by controlling shape and size at nanometer scale.(The Royal Society Report, July 2004) It is a multi-disciplinary subject involving the use of physics, chemistry, biology and engineering. There are two fundamentally different approaches to nanotechnology: “Top-down” is the production of nanoscale structures by taking a bulk material and forming it into a desired structure. “Bottom-up” refers to building organic and inorganic structures atom by atom or molecule by molecule. NANOPARTICLES Nanoparticles are solid colloidal particles consisting of macromolecular substances that vary in size f...
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PREPARATION OF HOSPITAL FORMULARY

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PREPARATION OF FORMULARY ·          Formulation is an essential part of hospital pharmacy. ·          It has been a focal point for improving drug therapy in hospitals. ·          Effectiveness of formulary system depends on the abilities of the pharmacist involved with it. ·          Although the majority of formulary decisions are made by Pharmacy and Therapeutic Committee but well planned system provides both structure and flexibility and encompasses both selection of drugs and criteria for drug use. ·          These special features allow for standardization to reduce errors, wastage and required personnel time. Advantage: ·          To discourage the use of “less than optimal drug therapy”, and ·     ...
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PLANT LAYOUT FOR CAPSULE MANUFACTURING DEPARTMENT & MANUFACTURING PROCESS

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PLANT LAYOUT  FOR CAPSULE MANUFACTURING DEPARTMENT: ENVIRONMENT CONDITION FOR CAPSULE FILLING AREA Humidity:          Not more than 35% RH Temperature:    Not more than 25% Area of each room, position of equipments, washing, drying, and sanitary facilities must be in accordance with GMP. MANUFACTURING PROCESS: CHEMCAPS Limited is an India based young and dynamic organization engaged in the manufacture and export of 'empty hard gelatin capsules' under the brand name of 'Chemlock' for discerning customers around the globe. COMPOSITION                                     Gelatin                                     Water                       ...
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2. Extensive literature survey:

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Once the problem is formulated, a brief summary of it should be written down. It is compulsory for a research worker writing a thesis for a Ph.D. degree to write a synopsis of the topic and submit it to the necessary Committee or the Research Board for approval.   At this juncture the researcher should undertake extensive literature survey connected with the problem. For this purpose, the abstracting and indexing journals and published or unpublished bibliographies are the first place to go to. Academic journals, conference proceedings, government reports, books etc., must be tapped depending on the nature of the problem. In this process, it should be remembered that one source will lead to another. The earlier studies, if any, which are similar to the study in hand, should be carefully studied. A good library will be a great help to the researcher at this stage.
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PREPARATION OF HOSPITAL FORMULARY

Image
PREPARATION OF FORMULARY ·          Formulation is an essential part of hospital pharmacy. ·          It has been a focal point for improving drug therapy in hospitals. ·          Effectiveness of formulary system depends on the abilities of the pharmacist involved with it. ·          Although the majority of formulary decisions are made by Pharmacy and Therapeutic Committee but well planned system provides both structure and flexibility and encompasses both selection of drugs and criteria for drug use. ·          These special features allow for standardization to reduce errors, wastage and required personnel time. Advantage: ·          To discourage the use of “less than optimal drug therapy”, and ·     ...
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